Selected publications

Alkan, H.F., Walter, K.E., Luengo, A., Madreiter-Sokolowski, C.T., Stryeck, S., Lau, A.N., Al-Zoughbi, W., Lewis, C.A., Thomas, C.J., Hoefler, G., Graier, W.F., Madl, T., Vander Heiden, M.G., Bogner-Strauss, J.G. Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting. Cell Metab Aug 14 (2018).

Muir, A., Danai, L.V., Vander Heiden, M.G. Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies. Dis Model Mech Aug 7; 11(8) (2018).

Sullivan, L.B., Luengo, A., Danai, L.V., Bush, L.N., Diehl, F.F., Hosios, A.M., Lau, A.N., Elmiligy, S., Malstrom, S., Lewis, C.A., Vander Heiden, M.G. Aspartate is an endogenous metabolic limitation for tumour growth. Nat Cell Biol Jul; 20(7): 782-788 (2018).

Danai, L.V., Babic, A., Rosenthal, M.H., Dennstedt, E.A., Muir, A., Lien, E.C., Mayers, J.R., Tai, K., Lau, A.N., Jones-Sali, P., Prado, C.M., Petersen, G.M., Takahashi, N., Sugimoto, M., Yeh, J.J., Lopez, N., Bardeesy, N., Fernandez-Del Castillo, C., Liss, A.S., Koong, A.C., Bui, J., Yuan, C., Welch, M.W., Brais, L.K., Kulke, M.H., Dennis, C., Clish, C.B., Wolpin, B.M., Vander Heiden, M.G. Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature Jun; 558(7711): 600-604 (2018).

Dayton, T.L., Gocheva, V., Miller, K.M., Bhutkar, A., Lewis, C.A., Bronson, R.T., Vander Heiden, M.G., Jacks, T. Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma. Cancer Metab May 31; 6:6 (2018).

Muir, A., Vander Heiden, M.G. The nutrient environment affects therapy. Science Jun 1; 360(6392): 962-963 (2018).

Hosios, A.M., Vander Heiden, M.G. The redox requirements of proliferating mammalian cells. J Biol Chem May 18; 293(20): 7490-7498 (2018).

Lau, A.N., Israelsen, W.J., Roper, J., Sinnamon, M.J., Georgeon, L., Dayton, T.L., Hillis, A.L., Yilmaz, O.H., Di Vizio, D., Hung, K.E., Vander Heiden, M.G. PKM2 is not required for colon cancer initiated by APC loss. Cancer Metab Nov 30; 5:10 (2017).

Muir, A., Danai, L.V., Gui, D.Y., Waingarten, C.Y., Lewis, C.A., Vander Heiden, M.G. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. Elife Aug 15 (2017).

Vander Heiden, M.G., DeBerardinis, R.J., Understanding the Intersections between Metabolism and Cancer Biology. Cell 168: 657-669 (2017).

Davidson, S.M., Jonas, O., Keibler, M.A., Hou, H.W., Luengo, A., Mayers, J.R., Wyckoff, J., Del Rosario, A.M., Whitman, M., Chin, C.R., Condon, K.J., Lammers, A., Kellersberger, K.A., Stall, B.K., Stephanopoulos, G., Bar-Sagi, D., Han, J., Rabinowitz, J.D., Cima, M.J., Langer, R., Vander Heiden, M.G. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat Med (2): 235-241 (2017).

Dayton, T.L., Jacks, T., Vander Heiden, M.G. PKM2, cancer metabolism, and the road ahead. EMBO Reports 17(12): 1721-1730 (2016).

Sullivan, L.B., Gui, D.Y., Vander Heiden, M.G. Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. Nat Rev Cancer 16(11): 680-693 (2016).

Gui, D.Y., Sullivan, L.B., Luengo, A., Hosios, A.M., Bush, L.N., Gitego, N., Davidson, S.M., Freinkman, E., Thomas, C.J., Vander Heiden, M.G. Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin. Cell Metabolism 24(5): 716-727 (2016).

Davidson, S.M., Vander Heiden, M.G. Critical Functions of the Lysosome in Cancer Biology. Annu Rev Pharmacol Toxicol (2016).

Mayers, J.R., Torrence, M.E., Danai, L.V., Papagiannakopeoulos, T., Davidson, S.M., Bauer, M.R., Lau, A.N., Ji, B.W., Dixit, P.D., Hosios, A.M., Muir, A., Chin, C.R., Freinkman, E., Jacks, T., Wolpin, B.M., Vitkup, D., Vander Heiden, M.G. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 353(6304): 1161-5 (2016).

Mattaini, K.R., Sullivan, M.R., Vander Heiden, M.G. The importance of serine metabolism in cancer. J Cell Biol 214(3): 249-57 (2016).

Dayton, T.L., Gocheva, V., Miller, K.M., Israelsen, W.J., Bhutkar, A., Clash, C.B., Davidson, S.M., Luengo, A., Bronson, R.T., Jacks, T., Vander Heiden, M.G. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev 30(9): 1020-33 (2016).

Hosios, A.M., Hecht, V.C., Danai, L.V., Johnson, M.O., Rathmell, J.C., Steinhauser, M.L., Manalis, S.R., and Vander Heiden, M.G. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev. Cell (2016).

Olenchock, B.A., Moslehi, J., Baik, A.H., Davidson, S.M., Williams, J., Gibson, W.J., Chakrabortty, A.A., Pierce, K.A., Miller, C.M., Hanse, E.A., Kelekar, A., Sullivan, L.B., Wagers, A.J., Clash, C.B., Vander Heiden, M.G., Kaelin W.G. Jr. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell 164(5): 884-95 (2016).

Davidson, S.M., Papagiannakopeoulos, T., Olenchock, B.A., Heyman, J.E., Keibler, M.A., Luengo, A., Bauer, M.R., Jha, A.K., O’Brien, J.P., Pierce, K.A., Gui, D.Y., Sullivan, L.B., Wasylenko, T.M., Subbaraj, L., Chin, C.R., Stephanopolous, G., Mott, B.T., Jacks, T., Clish, C.B., Vander Heiden, M.G.. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metab (2016).

Hosios A.M., Fiske B.P., Gui D.Y., Vander Heiden M.G. Lack of Evidence for PKM2 Protein Kinase Activity. Mol Cell 59(5): 850-7 (2015).

Sullivan L.B., Gui D.Y., Hosios A.M., Bush L.N., Freinkman E., Vander Heiden M.G. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. Cell 162(3): 552-63 (2015).

Mattaini K.R., Brignole E.J., Kini M., Davidson S.M., Fiske B.P., Drennan C.L., Vander Heiden M.G. An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation Cancer Metab 3:5 (2015).

Lunt, S.Y., Muralidhar, V., Hosios, A.M., Israelsen, W.J., Gui, D.Y., Newhouse, L., Ogrodzinski, M., Hecht, V., Xu, K., Marin Acevedo, P.N., Hollen, D.P., Bellinger, G., Dayton, T.L., Christen, S., Elia, I., Dinh, A.T., Stephanopoulos, G., Manalis, S.R., Yaffe, M.B., Andrechek, E.R., Fendt, S., Vander Heiden, M.G. Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation. Mol Cell 57(1): 95-107 (2015).

Mayers, J.R., Wu, C., Clish, C.B., Kraft, P., Torrence, M.E., Fiske, B.P., Yuan, C., Bao, Y., Townsend, M.K., Tworoger, S.S., Davidson, S.M., Papagiannakopoulos, T., Yang A., Dayton, T.L., Ogino, S., Stampfer, M.J., Giovannucci, E.L., Qian, Z.R., Rubinson, D.A., Ma, J., Sesso, H.D., Gaziano, J.M., Cochrane, B.B., Liu, S., Wactawski-Wende J., Manson, J.E., Pollak, M.N., Kimmelman, A.C., Souza, A., Pierce, K., Wang, T.J., Gerszten, R.E., Fuchs, C.S., Vander Heiden, M.G., Wolpin, B.M. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med 20(10): 1193-8 (2014).

Wang, Y.H., Israelsen, W.J., Lee, D., Yu, V.W., Jeanson, N.T., Clish, C.B., Cantley, L.C., Vander Heiden, M.G., Scadden, D.T. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell 158(6):1309-23 (2014).

Lewis, C.A., Parker, S.J., Fiske, B.P., McCloskey, D., Gui, D.Y., Green, C.R., Vokes, N.I. Feist, A.M., Vander Heiden, M.G., Metallo, C.M. Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells. Mol Cell 55(2):253-263 (2014).

Israelsen, W.J., Dayton, T.L., Davidson, S.M., Fiske, B.P., Hosios, A.M., Bellinger, G., Li, J., Yu, Y., Sasaki, M., Horner, J.W., Burga, L.N., Xie, J., Jurczak, M.J., DePinho, R.A., Clish, C.B., Jacks, T., Kibbey, R.G., Wulf, G.M., Di Vizio D., Mills, G.B., Cantley, L.C., Vander Heiden, M.G. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 155(2):397-409 (2013).

Commisso, C., Davidson, S.M., Soydaner-Azeloglu, R.G., Parker, S.J., Kamphorst, J.J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J.A., Thompson, C.B., Rabinowitz, J.D., Metallo, C.M., Vander Heiden, M.G., Bar-Sagi, D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497(7451):633-7 (2013).

Metallo, C.M. and Vander Heiden, M.G. Understanding metabolic regulation and its influence on cell physiology. Mol Cell 49(3):388-98 (2013).

Anastasiou, D., Yu, Y., Israelsen, W.J., Jiang, J.K., Boxer, M.B., Hong, B.S., Tempel, W., Dimov, S., Shen, M., Jha, A., Yang, H., Mattaini, K.R., Metallo, C.M., Fiske, B.P., Courtney, K.D., Malstrom, S., Khan, T.M., Kung, C., Skoumbourdis, A.P., Veith, H., Southall, N., Walsh, M.J., Brimacombe, K.R., Leister, W., Lunt, S.Y., Johnson, Z.R., Yen, K.E., Kunii, K., Davidson, S.M., Christofk, H.R., Austin, C.P., Inglese, J., Harris, M.H., Asara, J.M., Stephanopoulos, G., Salituro, F.G., Jin, S., Dang, L., Auld, D.S., Park, H.W., Cantley, L.C., Thomas, C.J., Vander Heiden, M.G. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. (2012).

Andronesi, O.C., Kim, G.S., Gerstner, E., Batchelor, T., Tzika, A.A., Fantin, V.R., Vander Heiden, M.G., Sorensen, A.G. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med. 4:116 (2012).

Metallo, C.M., Gameiro, P.A., Bell, E.L., Mattaini, K.R., Yang, J., Hiller, K., Jewell, CM., Johnson, Z.R., Irvine, D.J., Guarente, L., Kelleher, J.K., Vander Heiden, M.G., Iliopoulos, O., Stephanopoulos, G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481: 380-4 (2011)

Lunt, S.Y. and Vander Heiden, M.G. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 27: 441-64 (2011).

Vander Heiden, M.G. Targeting cancer metabolism: a therapeutic window opens. Nature Rev Drug Discov 10: 671-84 (2011).

Locasale, J.W., Grassian, A.R., Melman, T., Lyssiotis, C.A., Mattaini, K.R., Bass, A.J., Heffron, G., Metallo, C.M., Muranen, T., Sharfi, H., Sasaki, A.T., Anastasiou, D., Mullarky, E., Vokes, N.I., Sasaki, M., Beroukhim, R., Stephanopoulos, G., Ligon, A.H., Meyerson, M., Richardson A.L., Chin L., Wagner, G., Asara, J.M., Brugge, J.S., Cantley, L.C., Vander Heiden, M.G. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genetics 43: 869-74 (2011).

Vander Heiden, M.G. Targeting cell metabolism in cancer patients. Sci Transl Med 2:31ed1 (2010).

Dang, L., White, D.W., Gross, S., Bennett, B.D., Bittinger, M.A., Driggers, E.M., Fantin, V.R., Jang, H.G., Jin, S., Keenan, M.C., Marks, K.M., Prins, R.M., Ward, P.S., Yen, K.E., Liau, L.M., Rabinowitz, J.D., Cantley, L.C., Thompson, C.B., Vander Heiden, M.G., and Su, S.M. Cancer-associated IDH-1 mutations produce 2-hydroxyglutarate. Nature 462(7274):739-44 (2009).

Vander Heiden, M.G., Cantley, L.C., Thompson, C.B. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324: 1029-1033 (2009).